Work on earlier programmes such as ventilator associated pneumonia (VAP), biofilms and other indications carries on as research projects, including academic and/or commercial collaborations and grant funded programmes.
In line with this strategy, Destiny Pharma signed a research collaboration agreement with Aston University to examine novel compounds from the XF-platform and assess their potential to prevent, control and eradicate dangerous bacteria in biofilms. Serious infections are sometimes caused and exacerbated by biofilms where bacteria can hide and be protected from traditional anti-infective agents. XF compounds have already shown efficacy in biofilm models and this research project will explore the potential further, including looking at the mechanisms-of-action.
A second project was signed with Southampton University as a National Biofilms Innovation Centre (NBIC) funded research collaboration. The project will examine the use of the company’s novel XF compounds to prevent, control, and eradicate chronic clinical infections with underlying biofilm involvement, such as those in diabetic foot ulcers and cystic fibrosis.
A third grant was awarded in 2019 under the UK-China AMR fund. It will examine the potential for XF drugs to treat dermal and ocular infections and work has already started at Cardiff University.
Destiny Pharma also continued to strengthen its patent estate, with the grant of the XF biofilm patent in Canada in February 2018, bringing the total number of XF platform granted patents to 95.