Destiny Pharma is pleased to be highlighted in an analyst note from WH Ireland titled, “WHI Sector Comment: Strategic themes in healthcare: an AIM perspective“.
A copy of the report can be found here
News
04 November 2021 – SAB Member Prof. Gerding is Keynote at C.diff Conference
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Destiny Pharma’s SAB Member Professor Dale Gerding is Keynote Speaker at C. diff. International Conference
Brighton, United Kingdom – 4th November 2021 – Destiny Pharma (AIM: DEST), a clinical stage biotechnology company focused on the development of novel medicines to prevent life threatening infections, today announces that its Scientific Advisory Board Member, Professor Dale Gerding, MD, MACP, FIDSA, FSHEA, will be giving a keynote presentation at the C. diff International Conference & Health EXPO to be held in-person and virtually from 4th – 5th November 2021. Destiny Pharma is a Gold Sponsor of the event.
Prof. Gerding’s presentation titled ‘Adjunctive Therapy for CDI to Prevent Recurrence: What Works and Practical Issues’ will be at 7.20pm – 7.40pm GMT/ 2.20pm – 2.40pm EST on Friday 5th November 2021. Registration for the Conference can be found here.
Destiny Pharma’s late-stage asset, NTCD-M3, is a novel microbiome therapeutic being developed to reduce the recurrence of C. difficile infections (CDI) in the gut. CDI is the leading cause of hospital acquired infection in the US and current treatments lead to significant recurrence. In the US, there are approximately 500,000 cases of CDI each year; many of these initial cases then recur leading to 29,000 deaths per year.
Neil Clark, Chief Executive Officer of Destiny Pharma, said: “We are delighted to be sponsoring this important global event which raises C.difficile awareness and brings together patients and drug developers. We are also very proud to have our Scientific Advisory Member, Professor Dale Gerding invited as a Keynote Speaker. Prof. Gerding is a world-leading expert in C. difficile infections and the discoverer of NTCD-M3, Destiny Pharma’s Phase 3 ready microbiome therapeutic. NTCD-M3 has the potential to become the leading treatment for CDI, as its strong Phase 2 clinical data and target product profile shows clear advantages to both existing CDI treatment options and those currently in clinical development.”
-END-
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
+44 (0)1273 704 440
pressoffice@destinypharma.com
Optimum Strategic Communication
Hollie Vile / Manel Mateus / Vici Rabbetts
+44 (0) 208 078 4357
destinypharma@optimumcomms.com
finnCap Ltd (Nominated Adviser and Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0)20 7220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0)20 3705 9321
MC Services AG
Anne Hennecke / Andreas Burckhardt
+49-211-529252-0
About Destiny Pharma
Destiny Pharma is a clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections and has earlier grant funded XF research projects.
For further information, please visit https://www.destinypharma.com
Forward looking statements
Certain information contained in this announcement, including any information as to the Group’s strategy, plans or future financial or operating performance, constitutes “forward-looking statements”. These forward looking statements may be identified by the use of forward-looking terminology, including the terms “believes”, “estimates”, “anticipates”, “projects”, “expects”, “intends”, “aims”, “plans”, “predicts”, “may”, “will”, “seeks” “could” “targets” “assumes” “positioned” or “should” or, in each case, their negative or other variations or comparable terminology, or by discussions of strategy, plans, objectives, goals, future events or intentions. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this announcement and include statements regarding the intentions, beliefs or current expectations of the Directors concerning, among other things, the Group’s results of operations, financial condition, prospects, growth, strategies and the industries in which the Group operates. The directors of the company believe that the expectations reflected in these statements are reasonable, but may be affected by a number of variables which could cause actual results or trends to differ materially. Each forward-looking statement speaks only as of the date of the particular statement. By their nature, forward-looking statements involve risks and uncertainties because they relate to events and depend on circumstances that may or may not occur in the future or are beyond the Group’s control. Forward looking statements are not guarantees of future performance. Even if the Group’s actual results of operations, financial condition and the development of the industries in which the Group operates are consistent with the forward-looking statements contained in this document, those results or developments may not be indicative of results or developments in subsequent periods.
18 October 2021 – Major US hospital-based clinical trial highlights benefit of nasal decolonization to reduce ICU infections caused by Staphylococcus aureus
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Major US hospital-based clinical trial highlights benefit of nasal decolonization to reduce ICU infections caused by Staphylococcus aureus
Strong support for potential of XF-73 nasal product
as alternative to mupirocin
Brighton, United Kingdom – 18 October 2021 – Destiny Pharma (AIM: DEST), a clinical stage biotechnology company focused on the development of novel medicines to prevent life threatening infections, notes the important study report presented at the leading international conference, IDWeek virtual meeting which took place on 30 September – 3 October 2021.
The Phase 4 study [1] was the largest ever of this type, with over 300,000 patients which explored the link between Staphylococcus aureus decolonisation and Intensive Care Units (ICU) infection rates. S. aureus remains a formidable infection-causing pathogen in the ICU and is the primary bacterial pathogen causing ICU infections in the USA, responsible for 23% of all infections and nearly half (44%) of which are caused by the multi-antibiotic resistant strain, MRSA.
The study, Swap Out Trial, was a 4-year project led by the renowned hospital infection expert, Professor Susan Huang (Professor of Infectious Diseases at the University of California Irvine School of Medicine) in coordination with Healthcare Corporation America and support from the US Government’s Centers for Disease Control and Prevention (CDC). The study evaluated over 300,000 patients in 233 US ICU and compared levels of infection after the use of the current leading treatment, a nasal decolonisation antibiotic ointment – mupirocin – against a nasal antiseptic, iodophor. The main conclusion was that overall the nasal antibiotic mupirocin was shown to be superior for the reduction of S. aureus clinical cultures compared to the nasal antiseptic iodophor (p< 0.001).
The study has positive implications for Destiny Pharma’s novel XF-73 nasal gel which is being developed as a nasal S. aureus decolonisation medicine:
- The issue of mupirocin resistance remains a global concern and products which are as effective but do not cause Antimicrobial Resistance (AMR) are urgently needed
- The study indicates that the nasal antiseptic iodophor is not as effective as mupirocin and underlines the significant market opportunity for XF-73 as a much-needed new medicine for hospitals to help prevent infections in the ICU and the post-surgical setting
- XF-73 nasal gel has the potential to deliver a Target Product Profile (TPP) with significant advantages over mupirocin including;
- Effective nasal aureus decolonisation in 24 hours compared to 5 days for mupirocin (March 2021 Phase 2 data success)
- Significantly quicker decolonisation and thus more cost-effective
- Ultra-rapid bactericidal drug, novel mechanism of action and no propensity for resistance seen to its potent activity against MRSAs
- Easy to use, patient compliance, non-irritant nasal gel formulation
- Low cost of goods enabling pragmatic pricing/easier reimbursement
Destiny Pharma is currently in regulatory discussions concerning the appropriate Phase 3 clinical study design to enable marketing approval for XF-73 nasal gel in Europe and the USA.
Neil Clark, Chief Executive Officer of Destiny Pharma, said: “This large, multi-year study clearly supports the value of nasal treatment to remove S. aureus and shows yet again the significant interest in improving the efficacy of nasal decolonisation because it is a major contributor to delivering a reduction in post-surgical S. aureus infections.
“Destiny Pharma’s XF-73 nasal gel is focused on delivering a novel decolonisation treatment and following the excellent Phase 2 clinical data, reported earlier in 2021, we remain committed to finalising our Phase 3 plans and bringing XF-73 to the hospital market to meet this clear and substantial clinical need. The Company believes strongly that XF-73 has the potential to provide a major step change and improvement in S. aureus decolonisation compared to mupirocin; XF-73 is faster acting with a broader antimicrobial action. Furthermore, XF-73 does not generate resistance (AMR), which remains a major concern with the continuing use of mupirocin.”
[1] Presentation 4 – 137: Hospital Cluster-Randomized Trial of Mupirocin-Chlorhexidine vs Iodophor-Chlorhexidine for Universal Decolonization in Intensive Care Units (ICUs) (Mupirocin Iodophor Swap Out Trial).
-END-
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
pressoffice@destinypharma.com
+44 (0)1273 704 440
Optimum Strategic Communications
Mary Clark / Hollie Vile / Manel Mateus
destinypharma@optimumcomms.com
+44 (0) 208 078 4357
finnCap Ltd (Nominated Adviser and Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0)20 7220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0)20 3705 9321
MC Associates AG
Anne Hennecke / Andreas Burckhardt
+49-211-529252-0
About Destiny Pharma
Destiny Pharma is a clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections and has earlier grant funded XF research projects.
For further information, please visit https://www.destinypharma.com
Forward looking statements
Certain information contained in this announcement, including any information as to the Group’s strategy, plans or future financial or operating performance, constitutes “forward-looking statements”. These forward looking statements may be identified by the use of forward-looking terminology, including the terms “believes”, “estimates”, “anticipates”, “projects”, “expects”, “intends”, “aims”, “plans”, “predicts”, “may”, “will”, “seeks” “could” “targets” “assumes” “positioned” or “should” or, in each case, their negative or other variations or comparable terminology, or by discussions of strategy, plans, objectives, goals, future events or intentions. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this announcement and include statements regarding the intentions, beliefs or current expectations of the Directors concerning, among other things, the Group’s results of operations, financial condition, prospects, growth, strategies and the industries in which the Group operates. The directors of the company believe that the expectations reflected in these statements are reasonable, but may be affected by a number of variables which could cause actual results or trends to differ materially. Each forward-looking statement speaks only as of the date of the particular statement. By their nature, forward-looking statements involve risks and uncertainties because they relate to events and depend on circumstances that may or may not occur in the future or are beyond the Group’s control. Forward looking statements are not guarantees of future performance. Even if the Group’s actual results of operations, financial condition and the development of the industries in which the Group operates are consistent with the forward-looking statements contained in this document, those results or developments may not be indicative of results or developments in subsequent periods.
11 October 2021 – IDSA press release: Drug-resistant Infections Led to $1.9 Billion in Health Care Costs, More Than 10,000 Deaths Among Older Adults in One Year
New IDSA release highlights the urgent need for action after antibiotic-resistant infections led to $1.9 billion in health care costs, and more than 10,000 deaths, among older adults in one year. For full statement, please click on link below:-
27 September 2021 – Expansion of clinical pipeline
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Expansion of clinical pipeline
New XF-73 skin infection clinical programme planned to start in China led by existing partner, China Medical System Holdings Limited
Targeting prevention and treatment of superficial skin infections caused by bacteria
Brighton, United Kingdom – 27 September 2021 – Destiny Pharma (AIM: DEST), a clinical stage biotechnology company focused on the development of novel medicines to prevent life threatening infections, is pleased to announce that the Company’s China regional partner and investor, China Medical System Holdings Limited (CMS), is establishing a new programme with XF-73 targeting the prevention and treatment of superficial skin infections caused by bacteria.
The programme will be run in China and will be focused on delivering a novel product in the local regulatory environment. The project will be led, managed and funded by CMS. Destiny Pharma will contribute scientific advice as required through a steering committee to the expert dermatology team at CMS. CMS has an extensive portfolio of dermatology assets and an expert understanding of the market and its requirements through its existing sales and marketing infrastructure.
Destiny Pharma has cross-reference rights to data generated from the programme and, in the future, could start a similar skin infection clinical programme focused on commercial territories outside those held by CMS (China and other Asian countries excluding Japan).
Destiny Pharma is currently running its own dermal programme with XF-73 in a different indication targeting the prevention and treatment of serious infections associated with burns and open wounds. This programme is in collaboration with both the US government’s National Institute of Allergy and Infectious Diseases (NIAID), and as part of the Global AMR Innovation Fund (GAMRIF) funded UK-China bilateral partnership to tackle AMR which is managed by Innovate UK. This new CMS initiative adds a further, differentiated product to Destiny Pharma’s pipeline, leveraging off the very strong efficacy, formulation and safety package generated to date by the XF platform.
Neil Clark, Chief Executive Officer of Destiny Pharma said: “We are very pleased to announce the addition of this new XF-73 dermal clinical programme to our portfolio with our partner China Medical System Holdings Limited. We are looking forward to the future development of this programme as well as our other infection prevention assets as we continue to build a high quality, late-stage biotechnology company.”
-END-
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
+44 (0)1273 704 440
pressoffice@destinypharma.com
Optimum Strategic Communications
Mary Clark / Hollie Vile / Manel Mateus
DestinyPharma@optimumcomms.com
+44 (0) 208 078 4357
finnCap Ltd (Nominated Adviser and Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0)20 7220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0)20 3705 9321
MC Associates AG
Anne Hennecke / Andreas Burckhardt
+49-211-529252-0
About Destiny Pharma
Destiny Pharma is a clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections and has earlier grant funded XF research projects.
For further information, please visit https://www.destinypharma.com
Forward looking statements
Certain information contained in this announcement, including any information as to the Group’s strategy, plans or future financial or operating performance, constitutes “forward-looking statements”. These forward looking statements may be identified by the use of forward-looking terminology, including the terms “believes”, “estimates”, “anticipates”, “projects”, “expects”, “intends”, “aims”, “plans”, “predicts”, “may”, “will”, “seeks” “could” “targets” “assumes” “positioned” or “should” or, in each case, their negative or other variations or comparable terminology, or by discussions of strategy, plans, objectives, goals, future events or intentions. These forward-looking statements include all matters that are not historical facts. They appear in a number of places throughout this announcement and include statements regarding the intentions, beliefs or current expectations of the Directors concerning, among other things, the Group’s results of operations, financial condition, prospects, growth, strategies and the industries in which the Group operates. The directors of the company believe that the expectations reflected in these statements are reasonable, but may be affected by a number of variables which could cause actual results or trends to differ materially. Each forward-looking statement speaks only as of the date of the particular statement. By their nature, forward-looking statements involve risks and uncertainties because they relate to events and depend on circumstances that may or may not occur in the future or are beyond the Group’s control. Forward looking statements are not guarantees of future performance. Even if the Group’s actual results of operations, financial condition and the development of the industries in which the Group operates are consistent with the forward-looking statements contained in this document, those results or developments may not be indicative of results or developments in subsequent periods.
09 September 2021 – Interim results for the 6 months ended 30 June 2021
Destiny Pharma today announced its interim results for the 6 months ended 30 June 2021, which can be found here.
26 August 2021 – Notice of Interim Results and Investor Presentation
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Notice of Interim Results and Investor Presentation
Brighton, United Kingdom – 23rd August 2021 – Destiny Pharma plc (AIM: DEST), a clinical stage innovative biotechnology company focused on the development of novel medicines that can prevent life threatening infections, will announce its Interim Results for the period ended 30th June 2021, on Thursday 9th September 2021.
Neil Clark, Chief Executive Officer and Shaun Claydon, Chief Financial Officer, will provide a live presentation on the same day, at 09:30 am BST, followed by a Q&A session accessible via the Investor Meet Company platform. The webcast of the presentation will be available on the Company’s investor relations website at www.destinypharma.com.
The presentation is open to analysts and all existing and potential new shareholders. Questions can be submitted pre-event via the Investor Meet Company Dashboard up until 09:00 am BST the day before the meeting, or at any time during the live presentation.
Investors can sign up to Investor Meet Company for free, and add to meet Destiny Pharma plc via:
https://www.investormeetcompany.com/destiny-pharma-plc/register-investor
Investors who already follow Destiny Pharma plc on the Investor Meet Company platform will automatically be invited.
-END-
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
pressoffice@destinypharma.com
+44 (0)1273 704 440
Optimum Strategic Communications
Mary Clark / Hollie Vile / Manel Mateus
DestinyPharma@optimumcomms.com
+44 (0) 208 078 4357
finnCap Ltd (Nominated Advisor Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0) 207 220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0) 203 705 9330
About Destiny Pharma
Destiny Pharma is a clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections and has earlier grant funded XF research projects.
For further information, please visit www.destinypharma.com
02 August 2021 – Secondary endpoint analysis from Phase 2b trial
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Update on secondary endpoint analysis from recent positive Phase 2b trial
Cardiac surgery patients receiving XF-73 nasal gel exhibited a valuable,
sustained nasal reduction of Staphylococcus aureus
Brighton, United Kingdom, 2nd August 2021 – Destiny Pharma plc (AIM: DEST), a clinical stage innovative biotechnology company focused on the development of novel medicines that can prevent life threatening infections is pleased to announce additional, strong data from its recent Phase 2b clinical trial. In March 2021, the Company announced that this study had met its primary endpoint, demonstrating a highly significant reduction of 2.5 log (>99%) in nasal Staphylococcus aureus immediately prior to surgery compared to placebo (p<0.0001) after just 24 hours of XF-73 nasal gel dosing. The placebo-treated patients showed only a 0.4 log reduction in bacterial load immediately before surgery. All patients in the study also received antibiotic dosing as standard of care.
Today’s additional data shows that XF-73 dosed patients can also benefit from a sustained bacterial reduction at the three post-surgical sample time points after wound closure of 1 hour, 2 and 6 days demonstrating 2.5 log, 2.4 log and 2.8 log reductions, respectively, and sustaining the drop of over 99% in S. aureus nasal burden. The placebo treated patients reported 0.4 log, 1.5 log and 2.5 log reductions at the same time points. The bacterial reductions in XF-73 treated patients were shown to be highly statistically significant over placebo at the 1 hour and 2 days post-surgery timepoints (p<0.0001 and p<0.003, respectively). As a result of the antibiotic dosing used as standard of care, the 6-day time point reduction in the placebo group were equivalent to the XF-73 arm which was expected as it is known (*Wilson et al, 1977) that pre- and post-surgical systemic anti-staphylococcal antibiotic dosing elicits a slow, gradual reduction in nasal bacterial carriage.
This sustained nasal microbiological effect in the period of greatest risk (pre-surgery to wound healing) of XF-73 in patients is a desirable attribute for the reduction in the risk of acquiring a post-surgical, staphylococcal infection. Today’s new data demonstrates that XF-73 nasal gel has the potential to keep patients at a significantly low S. aureus nasal burden during the period of highest infection risk which runs from 1 hour prior to incision, during surgery itself, to the start of wound healing and out to at least 6 days post-surgery.
Neil Clark, CEO of Destiny Pharma, said: “We are very pleased to announce this additional, positive data from the successful Phase 2b study of XF-73 as a novel drug to reduce the incidence of post-surgical infections such as MRSA. We are having discussions with regulators in US and Europe to enable us to design the required Phase 3 clinical study and will announce further updates later in 2021. XF-73 has great potential to provide a safe, fast acting medicine that kills S. aureus in the nose prior to surgery thereby reducing patient infections whilst not generating bacterial resistance. There is a clear clinical need for such a new medicine that helps prevent post-surgical infections and there is a significant commercial opportunity.”
Scientific Advisory Board member, Professor Richard Proctor (Professor Emeritus of Departments of Medical Microbiology & Medicine at University of Wisconsin School of Medicine, Wisconsin, US), said: “This new clinical data from the Phase 2b trial wherein XF-73 produces a sustained reduction in nasal burden of S. aureus out to at least 6 days is an important observation for several reasons. First, nasal S. aureus burden directly correlates with the incidence of post-surgical wound infections. Second, reduction in S. aureus nasal colonization is associated with decreased numbers of all staphylococcal infections.”
*Wilson et al., In vivo effects of josamycin, erythromycin, and placebo therapy on nasal carriage of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy,1977, 3: p. 407-10)
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
pressoffice@destinypharma.com
+44 (0)1273 704 440
Optimum Strategic Communications
Mary Clark / Hollie Vile / Manel Mateus
DestinyPharma@optimumcomms.com
+44 (0) 208 078 4357
finnCap Ltd (Nominated Advisor Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0) 207 220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0) 203 705 9330
About Destiny Pharma
Destiny Pharma is a clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections and has earlier grant funded XF research projects.
For further information, please visit www.destinypharma.com
09 July 2021 – XF-73 Phase 2b data to be presented at ECCMID
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Successful XF-73 nasal gel Phase 2b study data to be presented at 2021 ECCMID Congress
- Infection prevention expert, Professor Julie Mangino MD to present XF-73 data abstract
Brighton, United Kingdom – 9th July 2021 – Destiny Pharma plc (AIM: DEST), a clinical stage innovative biotechnology company focused on the development of novel medicines to prevent life-threatening infections, today announces that an abstract providing analysis and discussion of the late-breaking data arising from the recently completed Phase 2b clinical study of XF-73 nasal gel will be presented at Europe’s premier antimicrobials congress, the 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) on Saturday, 10 July at 7:35 pm CET
Presentation Title: Repeated doses of exeporfinium chloride (XF-73) nasal gel over 24 hours significantly reduced the burden of Staphylococcus aureus nasal carriage in at-risk surgical patients: preliminary results from a Phase 2 study.
Presenting Author: Julie Mangino MD, FSHEA, FIDSA, Professor Emeritus, Department of Internal Medicine, Division of Infectious Diseases, The Ohio State University College of Medicine, US
Abstract #: 04905
Session: LB: Late breaking clinical trial data
Session code: S182
If you would like to meet with Destiny Pharma, please email us on conferences@destinypharma.com
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
+44 (0) 1273 704 440
pressoffice@destinypharma.com
Optimum Strategic Communications
Mary Clark/ Hollie Vile/ Manel Mateus
+44 (0) 203 174 1789
destinypharma@optimumcomms.com
finnCap Ltd (Nominated Advisor & Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0) 20 7220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0) 203 705 9330
About Destiny Pharma plc
Destiny Pharma is a UK based, clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence, which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections, and has earlier grant funded XF research projects.
For further information on the company, please visit https://www.destinypharma.com
About ECCMID
ECCMID (https://www.eccmid.org/) is Europe’s premier Clinical Microbiology & Infectious Diseases event, bringing together experts from many fields to present their latest findings, and developments and share their expertise. The scientific programme is built by the ECCMID Programme Committee, and independent group of experts representing all disciplines related to clinical microbiology and infectious diseases.
About XF-73
XF-73 is the lead drug candidate from Destiny Pharma’s XF platform, initially being developed for the prevention of post-surgical staphylococcal infections, such as methicillin-resistant Staphylococcus aureus (MRSA), which cause significant complications and increased healthcare costs in the hospital setting. XF-73 has been awarded both Qualified Infectious Disease Product (QIDP) and Fast Track status by the US FDA.
06 July 2021 – NTCD-M3 RD Agreement with US Dept Veterans Affairs
Destiny Pharma plc
(“Destiny Pharma” or “the Company”)
Destiny Pharma and US Department of Veterans Affairs enter into Cooperative Research and Development Agreement to further research NTCD-M3 for prevention of recurrence of Clostridioides difficile infections
Brighton, United Kingdom, 6 July 2021 – Destiny Pharma plc (AIM: DEST), a clinical stage innovative biotechnology company focused on the development of novel medicines that can prevent life threatening infections, is pleased to announce a Cooperative R&D agreement with the US Department of Veterans Affairs to support studies focusing on identifying new attributes for NTCD-M3, a novel microbiome therapeutic being developed to reduce the recurrence of Clostridioides difficile infections (CDI) in the gut.
Destiny Pharma will collaborate on this research project with the Edward Hines Jr. VA Hospital in Hines, Illinois, utilising their CDI research expertise to complete new preclinical studies that could support the administration of NTCD-M3 to a broader CDI patient population and therefore strengthen the market opportunity. The research project is planned to complete in Q4 2021. Financial terms are not disclosed.
Stuart Johnson, MD Professor of Medicine, Loyola Stritch School of Medicine, will lead the team conducting further studies of NTCD-M3 at the Edward Hines, Jr. VA Hospital, which has long been recognised for its advanced research into the diagnosis, epidemiology, prevention and treatment of CDI.
According to Prof. Johnson, “The potential for prevention of CDI with this non-toxigenic strain of C. difficile has been well-established. However, the mechanism of this protective effect has not been fully established. We are poised to conduct experiments that will help delineate the factors whereby NTCD-M3 prevents infection with toxigenic strains of this ubiquitous pathogen.”
CDI is the leading cause of hospital acquired infection in the US and current treatments lead to significant recurrence. In the US, there are approximately 500,000 cases of CDI each year; many of these initial cases then recur leading to 29,000 deaths per year.
NTCD-M3 has the potential to become the leading treatment for CDI prevention, as its Phase 2 data demonstrated a class leading 5% rate of recurrence compared to 30% with placebo.
The benefits of NTCD-M3 include:
- Single bacterial strain: a naturally occurring, single strain of a non-toxigenic bacteria;
- Excellent safety profile: well-defined treatment;
- Strong clinical data: NTCD-M3 recurrence rate of 5% versus 30% with placebo, which is “class leading”;
- Convenient treatment option: it is complementary to all current standard of care antibiotic treatments, administered as a single capsule once daily for seven days;
- Well-established manufacturing: will be manufactured at high volume and low cost with a long shelf life which should enable high uptake and a strong pharmacoeconomic position.
Destiny Pharma is progressing the plans for the single Phase 3 clinical study, the design of which has already been discussed with the US FDA, and which needs to be completed before submitting marketing authorisation applications in the US and Europe. The Phase 3 clinical study remains on schedule to commence in 2022.
Destiny Pharma has also commenced discussions with potential licensing partners and collaborators and is encouraged by the level of interest in the programme. The aim is to secure a partner to support the planned Phase 3 clinical study and participate in the future commercial launch of NTCD-M3.
Neil Clark, Chief Executive Officer of Destiny Pharma, said: “We are very pleased to be working with the expert CDI team at the Edward Hines, Jr. VA Hospital in Chicago. The planned study will help Destiny Pharma refine our planning for the NTCD-M3 Phase 3 study that we aim to start in 2022. There is a significant clinical and commercial opportunity for NTCD-M3 as a novel treatment to prevent the recurrence of CDI.”
For further information, please contact:
Destiny Pharma plc
Neil Clark, CEO
Shaun Claydon, CFO
pressoffice@destinypharma.com
+44 (0) 127 370 4440
Optimum Strategic Communications
Mary Clark/ Hollie Vile/ Manel Mateus
DestinyPharma@optimumcomms.com
+44 (0) 203 174 1789
finnCap Ltd (Nominated Advisor Joint Broker)
Geoff Nash / Kate Bannatyne, Corporate Finance
Alice Lane, Corporate Broking
+44 (0) 207 220 0500
WG Partners (Joint Broker)
Nigel Barnes / Claes Spång / Nigel Birks
+44 (0) 203 705 9330
About Destiny Pharma
Destiny Pharma is a clinical stage, innovative biotechnology company focused on the development of novel medicines that can prevent life-threatening infections. Its pipeline has novel microbiome-based biotherapeutics and XF drug clinical assets including NTCD-M3, a Phase 3 ready treatment for the prevention of C. difficile infection (CDI) recurrence which is the leading cause of hospital acquired infection in the US and also XF-73 nasal gel, which has recently completed a positive Phase 2b clinical trial targeting the prevention of post-surgical staphylococcal hospital infections including MRSA. It is also co-developing SPOR-COV, a novel, biotherapeutic product for the prevention of COVID-19 and other viral respiratory infections and has earlier grant funded XF research projects.
For further information, please visit www.destinypharma.com